Most sporadic colorectal cancers travel along a easily recognised progress from normal cells through adenoma (unnatural glandular growths) to malignant neoplastic disease, driven by mutations in a minuscule number of genes. RanplexCRC can simultaneously detect 28 mutations from four key genes in cancer or pre-cancer cells shed into the intestine. Selected mutations present in APC, KRAS, BRAF and Tp53, along with wild-type control sequences, are delineated on 2 biochips detected using Randox's Biochip Array Analysers.
The Randox family of Biochip Array analysers are immunoassay testing platforms that work by combining panels of related tests on a single biochip. The chemiluminescent endpoint is detected by a CCD-camera and quantified by a custom image-processing software. Evidence, a in full automated analyzer for high-throughput laboratories, and the Evidence Investigator, a semi-automated analyzer for low-throughput laboratories and research purposes, are both available from Randox.
Bowel (colorectal) cancer is the second largest cause of cancer mortality in the western world, but up to 90% curable if detected early. Unfortunately, near patients present with advanced disease, reducing their long term endurance. National Screening programmes ar being introduced throughout Europe, to reduce CRC mortality, using the FOB test. This inexpensive and noninvasive test detects blood in stool samples, which english hawthorn be an indication of a tumour. Patients with a positive FOB test are and so referred for colonoscopy. The FOB quiz, however, suffers from poor sensitivity, as not all tumours bleed (false electronegative test) and not all stool-blood is derived from tumours (false positive try out). Many patients (up to 50%) may therefore be sent for colonoscopies unnecessarily. Colonoscopies are invasive, involve dietary restrictions and demand the mien of a surgeon, so an intermediate test would benefit both the patient and the healthcare system. RanplexCRC provides the answer, filtering out false positives.
About Randox
Randox is an international diagnostics company, headquartered in the UK. Randox develop, manufacture and securities industry clinical diagnostic products world-wide. Core products are: Biochip Array Technology; clinical chemistry analysers and reagents; lineament controls and EQA; environmental diagnostics; recombinant proteins and antibodies.
Randox Laboratories
Diamond Road
Crumlin
Co. Antrim BT29 4QY
United Kingdom
http://www.randox.com
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